Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
نویسندگان
چکیده
منابع مشابه
Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very ...
متن کاملHydrophobically Modified Hydroxypropyl Methylcellulose in Rats
A six-month repeated-dose dermal toxicity study fo11owed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new ceLlulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats, Aqueous paste of HM-HPMC was applied to the skin ofrats once daily at dose levels up to 60 mg/kglday, which was the highest dose that could be ...
متن کاملHydroxypropyl methylcellulose in drug delivery
Hydroxy propyl methyl cellulose can be used in the development of different drug delivery technology. Nowadays it is a widely used polymer and different viscosity grade of this polymer is available. The hydrophilic and hydrophobic form (both variants) of this polymer is also available. This study includes a review of this polymer on use in different drug delivery system mosty focusing on more r...
متن کاملIn Vitro Studies of Controlled Release Alfuzosin Matrix Tablets Prepared with Ethylcellulose and Hydroxypropyl Methylcellulose
Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
متن کاملHydroxypropyl methylcellulose for the treatment of severe dry eye associated with Sjögren's syndrome.
Our purpose was to evaluate the efficacy of a new formulation of methylcellulose, preservative-free 0.5% hydroxypropyl methylcellulose (HPMC), for the treatment of dry eye. In the clinical part of our study, two groups of dry-eye patients, those with Sjögren's syndrome (SS) and those without (non-SS), were treated topically with 0.5% HPMC and evaluated for symptoms, ocular surface vital stainin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1992
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.17.21